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目的:观察中药抗感合剂治疗脓毒症患儿的临床疗效及其对血清肿瘤坏死因子(TNF-α)、白细胞介素(IL)-6水平的影响。方法:将60例确诊为脓毒症的患儿随机分为治疗组和对照组,所有患儿予常规抗炎、对症治疗,治疗组加服中药抗感合剂。2组疗程均为10天。观察2组疗程结束后的中医证候疗效及治疗前后TNF-α、IL-6水平的变化。结果:控显率治疗组为96.67%,对照组为80.00%,2组比较,差异有显著性意义(P<0.05)。2组治疗后TNF-α、IL-6水平均显著下降,与治疗前比较,差异均有显著性意义(P<0.05);2组治疗后TNF-α、IL-6水平比较,差异也有显著性意义(P<0.05)。结论:中药抗感合剂治疗小儿脓毒症有较好的临床疗效,抗感合剂能够降低炎症因子TNF-α、IL-6的水平。
Objective: To observe the clinical curative effect of Kanggan Mixture in treating children with sepsis and its effects on serum levels of tumor necrosis factor (TNF-α) and interleukin (IL) -6. Methods: Sixty children diagnosed as sepsis were randomly divided into treatment group and control group. All children were given routine anti-inflammatory and symptomatic treatment. The two groups were treated for 10 days. The curative effect of traditional Chinese medicine (TCM) and the changes of TNF-α and IL-6 levels before and after treatment were observed. Results: The control group was 96.67% in the treatment group and 80.00% in the control group. There was significant difference between the two groups (P <0.05). The levels of TNF-α and IL-6 in the two groups were significantly decreased after treatment, compared with those before treatment, the differences were significant (P <0.05). There was also a significant difference in the levels of TNF-α and IL-6 Sexual significance (P <0.05). Conclusion: The Chinese medicine Kanggan Mixture has a good clinical curative effect in pediatric sepsis. Anti-flu Mixture can reduce the levels of inflammatory cytokines TNF-α and IL-6.