肥大细胞是含颗粒的分泌细胞,主要分布于口腔粘膜的微血管床,可以在组织中移动,对周围细胞有刺激、抑制和毒性作用。口腔组织中的肥大细胞表达丝氨酸蛋白酶、类胰蛋白酶、胃促胰酶。肥大细胞的颗粒中含有肿瘤坏死因子-α(tumour necrosis factor-α,TNF),这些物质均起介质作用,脱颗粒后对内皮细胞和其它细胞施加影响。组织中肥大细胞的密度与E-selectin表达水平有关。E-selectin是一种内皮粘着分子,是嗜中性白细胞、T淋巴细胞、单核细胞和其它白细胞快速粘附至内皮细胞的关键。各种口腔粘膜的炎性损害均有 Mast cells are granule-containing secreting cells and are mainly distributed in the microvascular bed of the oral mucosa, which can move in the tissues and stimulate, inhibit and poison the surrounding cells. Mast cells in oral tissues express serine proteases, tryptase, and chymase. Mast cells contain tumor necrosis factor-alpha (TNF), which acts as a mediator and exerts effects on endothelial cells and other cells after degranulation. Tissue mast cell density and E-selectin expression levels. E-selectin is a type of endothelial adhesion molecule that is critical for the rapid adhesion of neutrophils, T-lymphocytes, monocytes and other white blood cells to endothelial cells. Various oral mucosal inflammatory lesions are