用观察染尘动物肺冲洗液中肺泡巨噬细胞和测定生化成分含量的方法,作为评价某种物质致纤维化能力的指标已引起学者们注意。实验证明,经气管内注入石英尘的大鼠肺冲洗液中脂质含量于染尘后短期内逐渐升高,而后又明显减少,降至染尘后早期水平。另有许多研究证明煤尘有减弱二氧化硅对肺组织的纤维化作用。本实验在于观察经气管内注入煤石英混合尘大鼠肺冲洗液中脂质含量的动态变化,以期为解释煤尘减弱二氧化硅的致纤维化作用有所帮助。 The observation of alveolar macrophages in lung-washing solution of stained animals and the determination of the biochemical content of them has been attracting the attention of scholars as an index for evaluating the fibrotic ability of a substance. Experiments show that the lipid content of rat lung rinse fluid injected into the lung by endotracheal tube gradually increases in the short term after being dyed, and then decreases significantly to the early level after dying. There are many other studies have shown that coal dust weakens the fibrosis of lungs by silica. The purpose of this experiment is to observe the dynamic changes of lipid content in the pulmonary irrigating solution of intratracheally injected coal-quartz mixed dust in order to help explain the fibrinolytic effect of coal dust to weaken the silica.