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目的了解正常海岛中晚期孕妇血清中部分肝功能指标的变化,并探讨其临床意义。方法采用Beckman Coulte LX20全自动生化分析仪对356例健康中晚期孕妇和312例健康体检非孕女性血清中的谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清碱性磷酸酶(ALP)、总胆汁酸(TBA)、α-L岩藻糖苷酶(AFU)、亮氨酰氨基肽酶(LAP)、谷氨酰转肽酶(GGT)七项指标进行对照检测。结果中晚期孕妇组血清中ALP、TBA、AFU、LAP四项指标检测结果显著高于对照组,差异有统计学意义(P<0.001),ALT、AST、GGT两组比较差异无统计学意义(P>0.05)。结论应高度重视妊娠中晚期孕妇血清中ALP、TBA、AFU、LAP的变化,并结合临床,以指导孕期保健工作。
Objective To understand the changes of some liver function indexes in the serums of middle and late pregnant women in normal sea areas and to explore its clinical significance. Methods Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (ALP), nitric oxide synthase (ALP) in serum of 356 healthy pregnant women and 312 healthy pregnant women were measured by Beckman Coulte LX20 automatic biochemical analyzer. TBA, AFU, LAP and GGT were detected by ELISA. Results The serum levels of ALP, TBA, AFU and LAP in the middle and late pregnant women were significantly higher than those in the control group (P <0.001). There were no significant differences in ALT, AST and GGT between the two groups P> 0.05). Conclusion The changes of ALP, TBA, AFU and LAP in serum of pregnant women in the second and third trimester of pregnancy should be attached great importance. Combined with the clinical practice, they should guide the health care during pregnancy.