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采用球囊血管成形术(BA)作用于粥样硬化狭窄的动脉,使管腔扩大,同时造成管壁撕裂,斑块碎裂。管壁内皮剥脱和内膜撕裂使血小板在损伤局部粘附和聚集,并通过释放一些生长因子刺激平滑肌细胞(SMC)增生,使管壁增厚,管腔再狭窄(RS)。聚集的血小板形成血小板血栓并机化,对管腔产生机械性阻塞作用。结果表明,RS形成过程中,管壁损伤是其形态学基础及始动环节;SMC增生是其中心环节;血小板的作用贯穿于RS形成过程的始终。
The use of balloon angioplasty (BA) in atherosclerotic stenosis artery, the lumen to expand, while causing the wall tear, plaque rupture. Endothelial disruption and intimal tear cause local adhesion and aggregation of platelets to the lesion and stimulate smooth muscle cell (SMC) proliferation by releasing some growth factors, thickening of the wall, and luminal restenosis (RS). Aggregated platelets thrombosis and the formation of platelet machine, the mechanical cavity obstruction. The results showed that during the formation of RS, the damage of the wall was the morphological foundation and the starting point of the process. The proliferation of SMC was the central part of it. The platelet function throughout the RS formation.