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中药青蒿为菊科植物黄花蒿(Artemisia annua L.),我国民间用于治疗疟疾。根据文献报道从该植物中分得蒿酮、异蒿酮、桉油精、左旋樟脑、α-丁香烯、β-丁香烯、异丁香烯、杜松烯、氧化丁香烯,倍半萜内酯有Arteannuin B(Ⅱ)、青蒿素(Ⅲ)、青蒿甲素(Ⅳ)、青蒿丙素(Ⅴ),此外,尚有香豆素和黄酮体等。我们从山东产的青蒿丙酮提取物经硅胶柱层析,除分得Arteannuin B、青蒿素、青蒿甲素外,还分得一新的倍半萜酸,定名为青蒿酸Artemisic acid,根据光谱分析,生源及化学反应确定其结构为(Ⅰ)。
The Chinese herbal medicine Artemisia annua L. is a member of the Artemisia annua L. plant. It is used for the treatment of malaria in China. According to reports from the literature, artemisinone, allophenone, eucalyptol, levocamphoryl, α-eugenene, β-syringene, isoeugenene, junienene, oxyurne, sesquiterpene lactone Arteannuin B (II), artemisinin (III), artemisinin (IV), artemisinin (V), and coumarin and flavonoids. We extracted the acetone extract of Artemisia annua L. from Shandong by silica gel column chromatography. In addition to Arteannuin B, artemisinin, and artemisinin A, we also obtained a new sesquiterpenic acid, named Artemisic acid. , According to spectral analysis, source and chemical reaction to determine its structure (I).