血管紧张素转化酶(ACE)存在于血管内皮细胞和单核-巨噬细胞系细胞中。作者报告2例恶性组织细胞病(MH)患者ACE活性升高。例1、男,52岁。因持续发热,体重减轻,进行性肝脾肿大和黄疸而入院。实验室检查:血红蛋白7.7g/d1,血小板60×10~9/l,胆红素9.7mg/dl,AKP147u/l,天冬氨酸转氨酶162u/l,丙氨酸转氨酶(ALT)7.7u/1,LDH 1656u/l。骨髓和肝脾活检显示α-醋酸萘酯酶染色阳性的异型组织细胞浸润,偶见吞噬红细胞现象。脾恶性组织细胞显示组织细胞超微结构特性——即胞浆丰富,有细小稠密颗粒,核大呈肾形,有中度核染色质凝聚,核仁明显。血清ACE活性显著增高(167u/l;正常15～45)。患者于活疗前 Angiotensin-converting enzyme (ACE) is present in vascular endothelial cells and monocyte-macrophage lineage cells. The authors report an increase in ACE activity in 2 patients with malignant histiocytosis (MH). Example 1, male, 52 years old. Due to persistent fever, weight loss, progressive hepatosplenomegaly and jaundice and admission. Laboratory tests: hemoglobin 7.7g / d1, platelets 60 × 10-9 / l, bilirubin 9.7mg / dl, AKP147u / l, aspartate aminotransferase 162u / l, alanine aminotransferase (ALT) 7.7u / 1, LDH 1656u / l. Bone marrow and liver and spleen biopsy showed that α-naphthyl acetate esterase positive staining of abnormal tissue cell infiltration, and occasionally phagocytosed erythrocyte phenomenon. Malignant splenic cells showed ultrastructural features of the tissue cells - that is, abundant cytoplasm, small dense particles, large kidney-shaped nuclei, moderate chromatin condensation, obvious nucleoli. Serum ACE activity was significantly higher (167u / l; normal 15-45). Patients before living therapy