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观察顺铂和放疗在治疗晚期宫颈癌中的作用。方法 从 1985年 3月至 1990年 8月 ,6 0例晚期宫颈癌患者接受单药顺铂 (DDP)化疗 ,DDP 2 0mg ,第 1～ 5日给药 ,同时放疗 ,配对抽取单纯放疗患者 6 0例供疗效对比观察。结果 化放组和单放组 5年生存率分别为 6 1 0 %和 44 0 % ,P <0 .0 5 ,Ⅲ期 5年生存率化放组高于单放组 (P <0 .0 5 ) ,化放组副作用主要是胃肠反应及骨髓抑制 ,单放组副反应不明显。结论 顺铂与放疗联合治疗Ⅲ期宫颈癌疗效好且副作用可以耐受。
To observe the role of cisplatin and radiotherapy in the treatment of advanced cervical cancer. Methods From March 1985 to August 1990, 60 patients with advanced cervical cancer received single-agent cisplatin (DDP) chemotherapy, DDP 20 mg, on the 1st to the 5th, while radiotherapy and paired radiotherapy alone 6 0 cases for the treatment of contrast observation. Results The 5-year survival rates of the chemotherapy group and the radiotherapy alone group were 61.0% and 44.0%, respectively, P <0.05. The 5-year survival rate of stage Ⅲ was higher than that of the radiotherapy alone group (P <0. 0) 5). The side effects of chemo-radiotherapy group were mainly gastrointestinal reaction and bone marrow suppression. The side effects of radiotherapy were not obvious. Conclusions The combination of cisplatin and radiotherapy in the treatment of stage Ⅲ cervical cancer has good curative effect and side effects can be tolerated.