作者报告一例在长期使用青霉素后发生寻常性天疱疮的病例。患者男,71岁。因无症状性神经梅毒,每日肌注普鲁卡因青霉素2.4g,口服丙磺舒2g。一周后于头皮部发生多发性散在的结痂性病变,直径0.7～5cm,后渐延及躯干与四肢,胸部有少数小的糜烂面,但无水疤。Nikolsky征阴性,口腔粘膜未累及。无天疱疮家族发病史,无青霉素过敏史,以往从未使用过青霉素。皮肤活检示寻常性天疱疮特征性的组织学和免疫 The authors report a case of pemphigus vulgaris occurring after prolonged use of penicillin. Patient male, 71 years old. Asymptomatic neurosyphilis, intramuscular procaine penicillin 2.4g, oral probenecid 2g. A week after the scalp occurred multiple scattered scaly lesions, diameter 0.7 ~ 5cm, after the gradual extension of the trunk and limbs, the chest a small number of small erosion surface, but no scars. Nikolsky sign negative, oral mucosa is not involved. No history of pemphigus family history, no history of penicillin allergies, ever used penicillin. Skin biopsy showed characteristic histology and immunity of pemphigus vulgaris