作者选择1991年1月至1992年4月间47例经组织学证实的复发性卵巢癌(均耐铂类化疗药物)病人进行研究。每位病人于紫杉醇治疗前常规查体,包括物理查体、CA125测定及CT等,每一疗程后重复上述检查,以判定疗效。白细胞2周查一次。 病人在ICU病房监护。将紫杉醇250mg/m~2溶于5％的葡萄糖液中,持续24小时静滴。滴完24小时后皮下使用G-CSF10μg/(kg.天)。如骨髓移植严重,剂量可增至20μg/(kg.天)。3周为一疗程。 评价疗效标准:①完全有效,查体及CT检查肿瘤全部消失,且CA125正常持续4周以上;②部分有效,经上述检查肿瘤直径减少 The authors selected 47 histologically confirmed patients with recurrent ovarian cancer (both resistant to platinum-based chemotherapy) from January 1991 to April 1992. Each patient in the paclitaxel routine examination before physical examination, including physical examination, CA125 determination and CT, etc., after each course of treatment to repeat the above tests to determine the efficacy. WBC 2 weeks check again. Patient in ICU ward custody. Paclitaxel 250mg / m ~ 2 dissolved in 5% glucose solution, intravenous infusion continued for 24 hours. G-CSF 10 μg / (kg. Day) was subcutaneously administered 24 hours after dripping. Such as severe bone marrow transplantation, the dose can be increased to 20μg / (kg. Days). 3 weeks for a course of treatment. Evaluation of efficacy criteria: ① completely effective, physical examination and CT examination of the tumor disappeared, and CA125 normal lasted more than 4 weeks; ② some effective, reduced by the above tumor diameter