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目的:分析2型糖尿病(T2DM)患者血清低密度脂蛋白(LDL)、胱抑素C(CysC)与动脉粥样硬化(AS)的相关性。方法:选取2型糖尿病患者300名,根据颈动脉内膜中膜厚度分为非动脉粥样硬化斑块组(n=109)和动脉粥样硬化斑块组(n=191),并对动脉粥样硬化斑块的相关危险因素进行多因素Logistic回归分析。结果:(1)Pearson相关分析显示,LDL、CysC水平与IMT值呈正相关(P<0.05)。(2)单因素分析示,非AS组和AS组两组间LDL(t=8.876,P<0.05)、CysC(t=7.985,P<0.05)、HbA1c(t=9.912,P<0.05)、Hs-CRP(t=12.461,P<0.05)、年龄(t=7.114,P<0.05)、UA((t=8.618,P<0.05)间差异有统计学意义;(3)多因素Logistic回归分析示,LDL、CysC、HbA1c、年龄是T2DM并AS的独立危险因素(P<0.05);结论:LDL与CysC水平是T2DM并AS的独立危险因素。
Objective: To analyze the correlation between serum low density lipoprotein (LDL), cystatin C (CysC) and atherosclerosis (AS) in type 2 diabetes mellitus (T2DM). Methods: 300 type 2 diabetic patients were selected and divided into non-atherosclerotic plaque group (n = 109) and atherosclerotic plaque group (n = 191) according to carotid artery intima-media thickness. Arterial Logistic regression analysis of related risk factors of atherosclerotic plaque was performed. Results: (1) Pearson correlation analysis showed that LDL and CysC levels were positively correlated with IMT (P <0.05). (2) Univariate analysis showed that the LDL (t = 8.876, P <0.05), CysC (t = 7.985, P <0.05), HbA1c (t = 9.912, Hs-CRP (t = 12.461, P <0.05), age (t = 7.114, P <0.05) and UA (t = 8.618, P <0.05); (3) Multivariate logistic regression analysis LDL, CysC, HbA1c, age were independent risk factors for T2DM and AS (P <0.05). Conclusion: The levels of LDL and CysC are independent risk factors of T2DM and AS.