【摘 要】
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Recent technical breakthroughs in cryo-electron microscopy (cryo-EM) revolutionized structural biology,which led to the 2017 Nobel Prize in chemistry being awar
【机 构】
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Department of Biophysics, College of Basic Medicine, Peking University Health Science Center, Peking
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Recent technical breakthroughs in cryo-electron microscopy (cryo-EM) revolutionized structural biology,which led to the 2017 Nobel Prize in chemistry being awarded to three scientists,Jacques Dubochet,Joachim Frank,and Richard Henderson,who made groundbreaking contributions to the development of cryo-EM.In this review,I will give a comprehensive review of the developmental history of cryo-EM,the technical aspects of the breakthrough in cryo-EM leading to the structural biology revolution,including electron microscopy,image recording devices and image processing algorithms,and the major scientific achievements by Chinese researchers employing cryo-EM,covering protein complexes involved in or related to gene expression and regulation,protein synthesis and degradation,membrane proteins,immunity,and viruses.Finally,I will give a perspective outlook on the development of cryo-EM in the future.
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