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目的:探究心肌肌钙蛋白Ⅰ在儿科心血管疾病中的临床应用。方法:选取本院在2014年1月~2015年12月收治的120例小儿心血管患者和120名同时期在我院体检的健康体检者作为观察对象。120例小儿心血管患者作为观察组,120名体检者作为对照组。对照组在空腹时抽取静脉血,观察组则在发病后4h抽取静脉血,分别检测两组血液中的心肌肌钙蛋白Ⅰ(cTnI)、肌红蛋白(Myo)和肌酸激酶同工酶(CK-MB)水平。结果:观察组患者的cTnI、Myo、CK-MB水平明显高于对照组,组间差异明显,具有统计学意义(P<0.05);并且cTnI、Myo、CK-MB对于观察组患者的敏感性分别为99.17%、90.00%、83.33%,明显高于对照组的3.33%、12.50%、8.33%,组间差异具有统计学意义(P<0.05)。结论:在儿科心血管疾病患者中,心肌肌钙蛋白I(cTnI)、肌红蛋白(Myo)和肌酸激酶同工酶(CK-MB)水平都会有明显的提升,并且cTnI、Myo、CK-MB指标对于心血管疾病患者的敏感性较高,可以作为诊断和预后的判断依据。
Objective: To investigate the clinical application of cardiac troponin Ⅰ in pediatric cardiovascular diseases. Methods: A total of 120 pediatric cardiovascular patients from January 2014 to December 2015 in our hospital and 120 healthy subjects undergoing physical examinations at the same period in our hospital were selected as the observation subjects. 120 cases of pediatric cardiovascular patients as the observation group, 120 subjects as a control group. In the control group, venous blood was drawn on fasting, while in the observation group, venous blood was drawn at 4 hours after the onset of symptoms. The levels of cTnI, Myo and creatine kinase isoenzyme ( CK-MB) levels. Results: The levels of cTnI, Myo and CK-MB in the observation group were significantly higher than those in the control group, with significant difference between the two groups (P <0.05); and the sensitivity of cTnI, Myo and CK-MB to the observation group (99.17%, 90.00% and 83.33% respectively), which were significantly higher than that of the control group (3.33%, 12.50% and 8.33%, respectively). There was significant difference between the two groups (P <0.05). CONCLUSIONS: Cardiac troponin I, myo and creatine kinase isoenzyme (CK-MB) levels are significantly elevated in pediatric patients with cardiovascular disease, and cTnI, Myo, CK MB index for patients with cardiovascular disease is more sensitive, can be used as a basis for diagnosis and prognosis.