为了增强吗啡的镇痛作用和消除其副作用,以往曾将镇痛剂(吗啡或利多尔、美沙酮)和拟肾上腺素药(苯丙胺、羟基苯丙胺、麻黄素、肾上腺素和去甲基肾上腺素)合用。伹根据近年来的报告:这种合用并不理想,因为在合用时,两者毒性均意外地增加。许多实验证明:小剂量苯丙胺能增加吗啡、利多尔和美沙酮的毒性。其增强程度主要取决于拟肾上腺素药的末 Analgesics (morphine or lidol, methadone) and adrenergic drugs (amphetamine, hydroxypropylpropylamine, ephedrine, epinephrine and norepinephrine) have been used together in order to enhance the analgesic effect of morphine and to eliminate its side effects .伹 According to reports in recent years, this combination is not ideal because the toxicity of both are unexpectedly increased when combined. Many experiments show that low-dose amphetamines increase the toxicity of morphine, lidol, and methadone. The degree of enhancement depends mainly on the end of adrenergic drugs