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目的分析艾滋病病毒(HIV)感染者合并单纯疱疹病毒2型(HSV-2)感染的情况,为采取综合性防治方案提供参考依据。方法将2008年1月至2010年9月,首次就诊于广州市第八人民医院,生殖器部位有疱疹样病变的患者的HSV-2DNA结果进行对比分析。结果共有117例,其中53例为HIV感染者,64例为非HIV感染者。HIV感染者合并HSV-2的检出率为67.92%(36/53),高于非HIV感染者的HSV-2检出率40.63%(26/64)。比较HIV/HSV-2联合感染与单纯HIV感染者的CD4+细胞数、CD4/CD8比值,两组间差异均无统计学意义(P>0.05)。结论应加强对HIV感染者HSV-2的筛查和治疗,减少通过单纯疱疹皮损所致的HIV传播。
Objective To analyze the prevalence of HSV-2 infection among people living with HIV (HIV) and provide a reference for comprehensive prevention and treatment programs. Methods From January 2008 to September 2010, the HSV-2 DNA results of patients who had herpes-like lesions in the genital area were compared for the first time in Guangzhou Eighth People’s Hospital. Results A total of 117 cases, of which 53 were HIV-infected, 64 were non-HIV-infected. The detection rate of HSV-2 in HIV-infected patients was 67.92% (36/53), which was higher than that of non-HIV-infected patients (40.63%, 26/64). Comparing the CD4 + cell count and CD4 / CD8 ratio of HIV / HSV-2 co-infected with HIV-infected individuals, there was no significant difference between the two groups (P> 0.05). Conclusions Screening and treatment of HSV-2 in HIV-infected patients should be strengthened to reduce the spread of HIV through herpes simplex lesions.