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为了分析和比较日本血吸虫病流行区人群细胞因子应答水平的差异，提供血吸虫病流行区人群细胞免疫应答特征的基线资料。以鄱阳湖中的南山岛上３个毗邻的自然村为研究现场，根据粪检结果对试区１４～４１岁人群按年龄组随机抽样，选取粪检结果阴性的６５人，粪检阳性的６４人为研究对象。采用全血培养法，以血吸虫可溶性虫卵抗原（ＳＥＡ）及可溶性成虫粗抗原（ＳＷＡＰ）刺激研究对象的血细胞产生细胞因子，检测培养上清中细胞因子的水平。结果表明，存在对血吸虫抗原刺激不产生相应细胞因子的个体，从细胞因子水平的均值来看，总体上，对ＳＥＡ的细胞因子应答水平较对ＳＷＡＰ的水平为高，每克粪卵数（ＥＰＧ）为０组的细胞因子平均水平显著高于ＥＰＧ大于０组的水平。研究结果提示，存在流行区人群细胞免疫应答水平被下调的可能性，其特征和机制值得进一步研究。
In order to analyze and compare the differences in the level of cytokine response in the endemic areas of schistosomiasis japonica, baseline data on the cellular immune responses in the population of schistosomiasis endemic areas were provided. Poyang Lake in Nanshan Island, three adjacent villages as the research site, according to the results of the fecal examination of 14 to 41-year-olds in the pilot area by age group random sampling, select the fecal negative results of 65 people, the manure positive 64 Research object The whole blood culture method was used to stimulate the cytokines produced by the hemolymph of schistosomiasis soluble egg antigen (SEA) and soluble adult antigen (SWAP) to detect the level of cytokines in the culture supernatant. The results showed that there was an individual that did not produce the corresponding cytokines for the stimulation of schistosome antigen. From the mean of the cytokine levels, in general, the level of cytokine response to SEA was higher than the level of SWAP and the number of eggs per gram (EPG ) As the average level of cytokines in group 0 was significantly higher than that of group EPG greater than 0. The results suggest that there is a possibility that the level of cellular immune response in endemic areas is down-regulated, and its characteristics and mechanisms deserve further study.