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目的:研究锦带花有效部位在体内抗流感病毒的作用。方法:建立在体流感病毒感染小鼠肺炎模型,通过观察小鼠肺部病变程度及指标,测定肺组织内流感病毒血凝滴度,判定锦带花各有效部位对小鼠肺炎的治疗作用。结果:口服锦带花乙酸乙酯提取物、正丁醇提取物及乙醇提取物能明显减轻小鼠肺组织病变程度,对肺组织内病毒的增殖有明显抑制作用,其中,乙酸乙酯提取物效果最为显著。结论:锦带花乙酸乙酯提取物、正丁醇提取物及乙醇提取物均具有良好的抗甲型流感病毒的作用,其中乙酸乙酯提取物效果最为显著,且呈剂量效应关系。
Objective: To study the anti-influenza virus effect of effective parts of Weigela indica in the body. Methods: The pneumonia model of mice infected with influenza virus was established. The degree of pulmonary lesions in mice and the indexes were determined. The titer of influenza virus in the lung tissue was determined. Results: Oral ethyl acetate extract, n-butanol extract and ethanol extract can significantly reduce the degree of lung tissue lesions in mice, the lung tissue significantly inhibited the proliferation of the virus, of which ethyl acetate extract The effect is the most obvious. Conclusion: Ethyl acetate extract, n-butanol extract and ethanol extract of Weihua flower have good anti-influenza A virus activity, of which ethyl acetate extract is the most effective and dose-effect relationship.