Purpose:To investigate gender differences in lens thickness (LT) and central anterior chamber depth (ACD) in normal subjects,and to assess age associated changes in these measures.Methods:The anterior chamber depth (ACD),and lens thickness (LT),of 150 normal subjects (150 eyes) was measured by anterior segment optical coherence tomography (ASOCT).Gender differences were assessed by independent ttest,and correlation analysis was used to examine the effect of Results:The mean values of ACD and LT were 2.69±0.32mm and 4.85±0.43 mm,respectively.Women had a significantly lower Mean ACD as compared to men (2.56±0.33 mm vs 2.85±0.29 mm; P ＜ 0.05).No statistically significant difference was found in LT between male and female subjects (P＞0.05).Correlation analysis findings suggest that LT increases with age (r=0.83,P ＜ 0.05),and that ACD decreases with age (r=-0.57,P ＜ 0.05).After controlling for LT,no significant correlation was observed between age and ACD (P＞0.05).Conclusion:The ACD of female subjects was,on average,shallower than that of their male counterparts.Aging was associated with increasing LT,and the observed narrowing of ACD with age,might be partially mediated by the increasing LT.