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目的探讨动态血压负荷对老年高血压病程度的评价作用及与靶器官损害的相关性。方法对≥60岁的正常血压和高血压人群监测动态血压、颈动脉内中膜厚度(Carotid intimal medial thickness,IMT)和颈动脉斑块,分别测量正常血压组(A组)、高压1级组(B组)、高血压2级组(C组)、高血压3级组(D组)血压负荷并进行对照,分析各级的血压负荷与IMT差别;对比颈动脉粥样硬化组(E组)和颈动脉正常组(F组)的血压负荷。结果与A组相比,B、C、D组即各高血压组血压负荷增加,IMT也增加;E组与F组比较,收缩血压负荷和夜间血压负荷显著增加,而舒张血压负荷增加不明显。结论动态血压负荷与老年高血压病靶器官损害相关,其中关系最密切的是收缩血压负荷和夜间血压负荷。
Objective To investigate the effect of ambulatory blood pressure load on the evaluation of the degree of hypertension in elderly patients and its relationship with the target organ damage. Methods The levels of ambulatory blood pressure, carotid intimal medial thickness (IMT) and carotid plaques in normotensive subjects with hypertension and hypertension were measured at ≥60 years. The levels of normotensive subjects (group A) (Group B), Hypertension Group 2 (Group C), Hypertension Grade 3 (Group D), and compared the blood pressure load and IMT at all levels. Compared with carotid atherosclerosis group (Group E) ) And normal carotid artery group (F group). Results Compared with group A, the blood pressure load in group B, C and D increased and the IMT increased. Compared with group F, the systolic blood pressure and nocturnal pressure increased significantly, while the diastolic blood pressure increased slightly . Conclusions The dynamic blood pressure load is related to the target organ damage in elderly patients with hypertension. Among them, the most closely related is the systolic blood pressure load and the nighttime blood pressure load.