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历史经验告诫不要行大角膜片移植,因易发生免疫排斥反应。这可能是由于郎格罕(Langerhans)细胞只见于周边角膜,而大角膜片靠近角膜缘的血管组织而提供大量的抗原。当角膜移植于血管密集的组织上时其免疫排斥率接近于其它有血管组织的排斥率。另外当植片直径大于10mm时会造成前房角的损害。但有时为了保留眼球和保存视力必须行大角膜植片移植。Young等曾报道以大角膜板层移植治疗严重的角巩膜炎。Tico等(1973)曾报道全角膜移
Historical experience warned not to be a large corneal graft, immune rejection prone. This may be due to the fact that Langerhans cells are found only in the peripheral cornea, whereas the large corneal flap provides a large amount of antigen near the limbal vascular tissue. When the cornea transplanted to the vascular dense tissue when its immune rejection rate is close to other vascular tissue rejection rate. In addition, when the diameter of the implant is more than 10mm, the anterior chamber angle will be damaged. But sometimes in order to preserve the eye and save vision must be a large corneal graft. Young et al. Have reported the treatment of severe scleritis with large corneal lamellar grafts. Tico et al. (1973) reported a total corneal shift