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目的 观察洛赛克、利君沙、呋喃唑酮三联短程治疗幽门螺杆菌(HP)感染阳性的消化性溃疡 (PU)疗效。方法 经胃镜、尿素酶、组织学染色检查确诊的 5 9例HP阳性的PU患者随机分为二组 :洛赛克加利君沙加呋喃唑酮组 ,洛赛克服药 2周 ,利君沙、呋喃唑酮服药 1 0天 ;雷尼替丁加呋喃唑酮组 ,雷尼替丁服药 4周 ,呋喃唑酮 1 0天。 6周后胃镜复查溃疡愈合情况 ,尿素酶、Giemsa染色检测HP。结果 洛赛克组溃疡愈合率为 90 .3% ,HP根除率为 87.1 % ,疼痛缓解时间为 3.1±1 .2天。与雷尼替丁组相比有显著性差异 (p <0 .0 5 )。结论洛赛克三联方案用药时间短 ,疗效好 ,提示利君沙有很强的抗HP作用 ,且与呋喃唑酮有协同作用 ,副作用少 ,价格适中 ,适宜在基层使用。
Objective To observe the curative effect of triple therapy of Losec, Lijun sand and furazolidone on peptic ulcer (PU) with positive Helicobacter pylori (HP) infection. Methods Fifty-nine patients with HP-positive PU diagnosed by gastroscope, urease and histological staining were randomly divided into two groups: Losec plus Gallijugar plus Furazolidone, Losec with 2 weeks, Lijun sand, Furazolidone Medication 10 days; ranitidine plus furazolidone group, ranitidine 4 weeks, furazolidone 10 days. Six weeks after endoscopy, ulcer healing was examined, and urease and Giemsa staining were used to detect HP. Results The rate of ulcer healing in Losec group was 90.3%, HP eradication rate was 87.1% and pain relief time was 3.1 ± 1.2 days. There was a significant difference compared with ranitidine group (p <0.05). Conclusions Losec triple therapy has short medication duration and good curative effect, suggesting that Li Jun Sha has a strong anti-HP effect and has synergistic effect with furazolidone with few side effects and moderate price, which is suitable for use at the grassroots level.