据报告,十二指肠和胃溃疡用甲腈咪胍作维持治疗1年,其复发率为15～20%。近10年来,已用壁细胞迷走神经切断术(parietal-cell vagotomy,PCV)作为十二指肠溃疡的选择性手术,它较之胃窦部切除术和其它种类的迷走神经切断术死亡率低,副作用少。但由于甲腈咪胍的应用,手术病人随之减少。本文研究对患有十二指肠或幽门前区溃疡的病人能否用长期甲腈咪胍治疗代替手术疗法。病人和方法85例经内窥镜或X线证实为重度幽门区溃疡,病史至少有3年,都有手术适应症。幽门区和距幽门2cm以内的活动性溃疡列入本组。基本治疗:全部病人用甲腈咪E胍治疗6～8周,溃疡愈合以 It has been reported that duodenal and gastric ulcer with clididine for maintenance treatment for 1 year, the recurrence rate was 15 to 20%. In recent 10 years, parietal-cell vagotomy (PCV) has been used as a selective procedure for duodenal ulcers, which has a lower mortality rate than antrum resection and other types of vagotomy, with side effects less. However, due to the use of cimetidine, the number of surgical patients is reduced. This article studies whether patients with duodenal or pyloric ulcers can use long-term cimetidine instead of surgery. Patients and Methods 85 cases of endoscopic or X-ray confirmed severe pyloric ulcer, a history of at least 3 years, have surgical indications. Pylorus and pylorus within 2cm from the active ulcers included in this group. Basic treatment: All patients treated with nitrile eGuanidine 6 to 8 weeks, the ulcer healed