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患者男性、38岁,1982年9月因发热,胸骨痛,经外周血及骨髓检查诊断为急性淋巴细胞性白血病,当即开始以强的松、VCR及羟基脲联合化疗,2月后血象及骨髓象先后完全缓解,以后每2个月以同方案维持治疗二周,每6周鞘内注射MTX10mg。1983年4月因头痛,呕吐经腰穿诊断为脑膜白血病,于鞘内注射MTX10mg及氟美松5mg 2次后脑脊液恢复正常。1983年10月脑性白血病复发,鞘内注射MTX3次疗效欠
Male, 38 years old, September 1982 due to fever, chest pain, peripheral blood and bone marrow examination diagnosed as acute lymphoblastic leukemia, immediately began with prednisone, VCR and hydroxyurea combination chemotherapy, blood and bone marrow after 2 months As has been completely relieved, after every two months to maintain the same program for two weeks, 6 weeks intrathecal injection of MTX10mg. 1983 April due to headache, vomiting, lumbar puncture diagnosis of leukemia by meningitis, intrathecal injection of MTX10mg and 5mg of dexamethasone 2 times after cerebrospinal fluid returned to normal. October 1983 recurrent cerebral leukemia, intrathecal injection of MTX3 times less effective