慢性粒细胞白血病(慢性)为多能干细胞水平上的恶性变引起的一种克隆性疾病.95%以上患者有脾脏肿大.兹将2例无脾肿大慢粒者报告如下.例1,谢某某,女,44岁,1973年因发热而就诊,白细胞数20×10~(?)/L,并见幼稚粒。骨髓增生明显活跃,粒:红为13.4:1,原始粒0.01、早幼0.015、中幼0.07、晚幼0.022,杆状加分叶核0.049,嗜酸粒0.05,嗜硷粒0.015.NAP 弱阳性,A 超未发现肝脾肿大.间断服用马利蓝及(或)靛玉红治疗,存活13年,1986年6月 A 超、B 超肝脾大小正常.NAP阴性,核型:46,xx,t(9:22)(q34;q11),诊断:慢粒(慢性期),ph~1(+).例2,刘某某,女,37岁,因贫血(Hb97g/L)住院.A 超肝脾不肿大,白细胞63×10~(?)/L,幼稚粒0.026.血小板353×10~(?)/L,骨髓增生极度活跃,粒:红为13.7:1,原始粒0.01,早幼0.034,中幼 Chronic myeloid leukemia (chronic) is a clonal disease caused by malignant transformation at the level of pluripotent stem cells, with splenomegaly in more than 95% of patients.Two cases of splenomegaly without splenomegaly are reported as follows: Example 1: Xie Moumou, female, 44 years old, in 1973 due to fever and treatment, the number of white blood cells 20 × 10 ~ (?) / L, and see the juvenile tablets. Myeloid hyperplasia was obviously active, granule: Red was 13.4: 1, original granule was 0.01, young and early as young as 0.015, young and middle-aged were 0.07, young and young was 0.022, lobular plus leaves 0.049, eosinophil 0.05 and alkaloid 0.015. , A was found no hepatosplenomegaly.Under intermittent use of blue and (or) indirubin treatment, survival of 13 years, in June 1986 A super, B super-liver and spleen size is normal.NAP negative, karyotype: 46, Case 2, Liu Moumou, female, 37 years old, hospitalized for anemia (Hb 97g / L) .A super liver and spleen does not enlarge, leukocyte 63 × 10 ~ (?) / L, immature grain 0.026. Platelet 353 × 10 ~ (?) / L, bone marrow hyperplasia extremely active, grain: red is 13.7: 0.01, as early as 0.034, young