哥伦比亚大学的W.C.Still和V.J.Novack在合成外消旋3-deoxyrouranolide时发现了一种化学现象:可用大环化合物的构象选择来控制反应的立体化学[J.Am.Chem.Soc.,106,1148(1984)]。这一发现使得人们借助很少几个光学活性中心就能在分子中寓这些活性中心较远处产生新的不对称原子,有朝一日,还可用这种方法事先计算为我们所需要的旋向反应的中间产物。 WCStill and VJ Novack of Columbia University discovered a chemical phenomenon in the synthesis of racemic 3-deoxyrouranolide: the stereochemistry of the reaction can be controlled by the conformational choice of macrocyclic compounds [J. Am. Chem. Soc., 106, 1148 (1984)]. This discovery makes it possible to generate new asymmetric atoms far away from these active centers in molecules by virtue of a few optical active centers. One day, this method can be used to calculate in advance the direction of rotation we need mid product.