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目的探讨小剂量米索前列醇用于足月妊娠引产的安全性和有效性。方法选择本院2007年3～8月收治的单胎有引产指征的初产妇80例,随机分为两组,观察组(米索前列醇组)40例,以25μg米索前列醇阴道后穹窿放置,6h后未临产者再次放置一次,无效者第2天重复。对照组(催产素组)40例,常规静脉滴注催产素。结果观察组促宫颈成熟显效率及引产总有效率均高于对照组(P<0.01),用药至临产时间、用药至分娩时间均短于对照组(P<0.05),剖宫产率低于对照组(P<0.01),产后2h出血量、新生儿窒息、新生儿出生体质量两组比较差异无统计学意义(P>0.05)。结论小剂量米索前列醇用于足月妊娠引产,安全有效,值得临床推广。
Objective To investigate the safety and efficacy of low-dose misoprostol for induction of labor during term pregnancy. Methods 80 cases of primipara caused by induction of labor were selected from March 2007 to August 2007 in our hospital. Randomly divided into two groups, 40 cases in the observation group (misoprostol group) and 25 μg misoprostol vagina Fornix placed, 6h unprofessional placed again, invalid 2 days repeated. Control group (oxytocin group) 40 cases, routine intravenous oxytocin. Results The effective rate of cervical ripening and the total effective rate of labor induction in the observation group were all higher than those in the control group (P <0.01). The time from medication to labor, medication to delivery time were shorter than those in the control group (P <0.05) Control group (P <0.01), 2h postpartum hemorrhage, neonatal asphyxia, neonatal birth weight between the two groups showed no significant difference (P> 0.05). Conclusion Small doses of misoprostol for full-term pregnancy induction of labor, safe and effective, worthy of clinical promotion.