论文部分内容阅读
长期以来,口服头孢菌素抗生素相继问世。第一代头孢菌素有头孢氨苄、头孢克罗等,接着又开发了头孢呋新酯、Cefixime、Cefteram Pivoxil、Cefpodoxime proxetil等第二代和第三代头孢菌素。最近由藤泽公司推出了Cefdinir(DFDN,FK482),其结构式见图。7-氨基头孢烷酸的3位上有一乙烯基,7位上有氨噻唑基和肟基。化学名为(6 R、7 R)-7-〔(Z〕-2-(2-氨基-4-噻唑)-2-肟基乙酰胺基〕-8-氧-3-乙烯基-5-硫杂-1-氮杂二环〔4,2,0〕辛-2-烯-2-羧酸。分子量395.42,分子式C_(14)H_(13)N_5O_5S_2。白色或带褐黄色的结晶性粉末,无嗅或稍带特异的气味,无味。
For a long time, oral cephalosporin antibiotics have come out. The first-generation cephalosporins have cephalexin, cefaclor and so on, and then developed cefuroxime axetil, Cefixime, Cefteram Pivoxil, Cefpodoxime proxetil second-generation and third-generation cephalosporins. Recently launched by Fujisawa Cefdinir (DFDN, FK482), the structural formula shown. The 7-aminocephalosporanic acid has a vinyl group at the 3-position and an aminothiazolyl group and an oxime group at the 7-position. (6R, 7R) -7 - [(Z) -2- (2-Amino-4-thiazolyl) -2- oximinoacetamido] -8-oxo-3-vinyl-5- Thia-1-azabicyclo [4,2,0] oct-2-ene-2-carboxylic acid, molecular weight 395.42, molecular formula C_ (14) H_ (13) N_5O_5S_2 white or brownish yellow crystalline powder , Odorless or slightly specific odor, tasteless.