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用Ｘ晶体衍射测定了氨基醇类抗疟药本芴醇（ｂｅｎｆｌｕｍｅｔｏｌＩ）的单晶结构，并与已知同类抗疟药金鸡纳生物碱进行了比较。再一次说明了氨基醇类化合物产生抗疟作用的三维空间结构特征。本芴醇的芴环平面与对氯苯基平面的二面角为５２８°。分子内ＮＯ距离为２７０９Ａ，这一距离与金鸡纳生物碱分子内脂肪氮原子与氧原子之间距离相近。侧链中ＮＣＣＯ的扭转角为４７６°。本芴醇单晶结构中存在分子内氢键，而未发现分子间氢键，这与以往认为产生抗疟作用的氨基醇类化合物存在分子间氢键而无分子内氢键不同。
The crystal structure of benflumetol, an aminoalcoholic antimalarial drug, was determined by X-ray crystallography and compared with the known antifungal cinchona alkaloids. Once again illustrates the three-dimensional structure of the amino alcohol compounds have antimalarial effects. The dihedral angle of the fluorene ring between the fluorene ring plane and the p-chlorophenyl plane was 52.8 °. Within the molecule N O distance of 2 709A, this distance and cinchona alkaloids within the molecular distance between aliphatic nitrogen atoms and oxygen atoms are similar. N-C C O in the side chain torsion angle of 47 6 °. The intramolecular hydrogen bonds in the lumefantrine single crystal structure, but no intermolecular hydrogen bonds were found, which is different from the amino alcohol compounds that were previously thought to have anti-malarial effects.