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目的:探讨改良后的黄体期超长方案降调节在子宫内膜异位症(EMs)和卵巢储备功能稍低患者行IVF治疗中的临床效果。方法:选取行IVF并确诊为EMs的患者112例,其中58例患者给予传统黄体期长效长方案降调节作为对照组,54例患者第1次降调节不理想后再次给予降调节者作为研究组,对比分析研究组和对照组患者的周期取消率、促性腺激素(Gn)使用量、Gn使用天数、获卵数、受精率、临床妊娠率、早期流产率及重度卵巢过度刺激综合征(OHSS)发生率。结果:研究组患者的临床妊娠率和受精率提高,周期取消率、流产率和重度OHSS发生率都有所降低。结论:改良黄体期长方案能够提高EMs患者的临床妊娠率和受精率,同时减少了周期取消率,是一种经济有效的降调节方案。
OBJECTIVE: To investigate the clinical effect of modified long term regimen of luteal phase in IVF treatment in endometriosis (EMs) and patients with slightly lower ovarian reserve. Methods: One hundred and twelve patients with IVF diagnosed as EMs were selected. Among them, 58 patients were given traditional long-term regimen of luteinizing regimen as control group. (Gn), days of Gn use, number of oocytes retrieved, fertilization rate, clinical pregnancy rate, early miscarriage rate and severe ovarian hyperstimulation syndrome (control group) were compared between the study group and the control group OHSS) incidence. Results: The clinical pregnancy rate and fertilization rate of the study group patients were improved, and the cycle cancellation rate, abortion rate and severe OHSS incidence decreased. CONCLUSION: The modified luteal phase long protocol can improve clinical pregnancy rate and fertilization rate of patients with EMs, and reduce the cycle cancellation rate. It is a cost-effective regulative program.