论文部分内容阅读
目前,我们尚未见有关中药治疗前后肺癌组织中细胞凋亡指数变化的报道.1996年2月～1997年6月,我们采用原位末端标记(ISEL)技术检测了76例非小细胞肺癌(NSCLC)治疗前后癌组织中的细胞凋亡指数,并探讨其临床意义.1 材料与方法1.1 一般资料本组76例晚期非小细胞肺癌中,男47例,女29例;年龄30岁～79岁,平均60.3岁.其中鳞癌52例,腺癌19例,低分化癌2例、细胞分类不明者3例.按肺癌TNM分期国际标准分期,其中Ⅲa期1例,Ⅲb期2例,Ⅳ期73例.按患者入院时间为序随机分为中药组40例、化疗组36例.两组均为初治患者,病程为1～5个月,分期基本相同,具有可比性.1.2 治疗方法根据患者心脏的情况,化疗选用CAP或CMP方案(环磷酰胺、阿霉素、丝裂霉素、顺氯氨铂).化疗组每3～4周重复1次,治疗3次为1疗程;中药组在化疗的同时服用自拟的“益元健中汤(人参、黄芪、
At present, we have not yet seen reports of apoptosis changes in lung cancer before and after treatment of traditional Chinese medicine. From February 1996 to June 1997, we used in situ end-labeling (ISEL) to detect 76 cases of non-small cell lung cancer (NSCLC). ) Apoptosis index in cancer tissues before and after treatment, and to explore its clinical significance. 1 Materials and methods 1.1 General information of 76 cases of advanced non-small cell lung cancer in the group, 47 males and 29 females; aged 30 to 79 years old The average age was 60.3 years. There were 52 cases of squamous cell carcinoma, 19 cases of adenocarcinoma, 2 cases of poorly differentiated carcinoma, and 3 cases of unknown cell classification. According to the international standard of lung cancer TNM staging, 1 case was in stage IIIa, 2 cases in stage IIIb, stage IV. 73 patients were randomly divided into Chinese medicine group 40 cases and chemotherapy group 36 cases according to the time of patient admission. Both groups were untreated patients and the disease duration was 1 to 5 months. The stage was basically the same and comparable. 1.2 Treatment method according to In the patient’s heart condition, chemotherapy was performed using CAP or CMP regimens (cyclophosphamide, doxorubicin, mitomycin, cisplatin). The chemotherapy group was repeated once every 3 to 4 weeks, and 3 treatments were given as 1 course of treatment; The group took self-made “Yiwon Jianzhong Decoction” (Ginseng, Huang Qi,