儿童再发性腹痛与幽门螺杆菌感染关系探讨

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对123例非精神心里因素所致的再发性腹痛(RAP)患儿进行胃镜检查及幽门螺杆菌(HP)检测。胃镜所见:正常17例(138%),慢性胃炎(CG)66例(537%),CG合并十二指肠球炎13例(106%)、合并食管炎4例(32%),消化性溃疡(PU)22例(179%),幽门管狭窄1例(08%)。采用三种方法检测HP:ELISA方法、PCR技术及组织学染色找菌,HP阳性率577%。123例中66例进行了病理学检查,观察到胃炎炎症程度与HP感染相关,66例中胃窦粘膜活检正常6例,Giemsa染色找菌HP全部阴性,轻度CG37例Giemsa染色HP阳性11例(11/37),中重度22例HP均为阳性。本组资料显示儿童RAP多数存在器质性病变,并与HP感染有关。对非精神性RAP、尤其血清HPIgG抗体及胃液HPPCR检测阳性者应进一步做胃镜检查以明确诊断。 Gastroscopy and Helicobacter pylori (HP) tests were performed in 123 children with recurrent abdominal pain (RAP) due to non-mental heart disease. Gastroscopy showed 17 cases (13.8%) of normal, 66 cases (53.7%) of chronic gastritis (CG), 13 cases (10.6%) of CG combined with duodenal inflammation and 4 cases of esophagitis (32%), peptic ulcer (PU) in 22 cases (179%) and pyloric stenosis in 1 case (08%). Three methods were used to detect HP: ELISA method, PCR and histological staining showed that the positive rate of HP was 577%. Among the 123 cases, 66 cases were pathologically examined. The degree of gastritis was found to be associated with HP infection. Sixty-six cases had a normal gastric mucosa biopsy, all were negative for Giemsa staining, and 11 were positive for CG37 with a Giemsa stain (11/37), moderate and severe 22 cases of HP were positive. This group of data show that most children with organic disease RAP, and with HP infection. On the non-spiritual RAP, in particular, serum HP IgG and gastric juice HP PCR test positive gastroscopy should be further done to confirm the diagnosis.
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