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按降糖药物的筛选规程[1] ;通过药效学试验证明消渴舒每日 15g/Kg、7 5g/Kg的剂量灌胃给药后 ,对正常动物血糖值有明显降低作用 (P <0 0 5 ) ,对肾上腺素引起的高血糖小白鼠有明显抑制作用 ,与空白对照组比较有显著性差异 (P <0 0 1) ,对四氧嘧啶引起糖尿病的动物有明显减轻作用 ,用药前后血糖有显著变化 ,连续给大鼠灌服 30d对实验性高血脂症的形成与高血脂模型组比较 ,血清总胆固醇 (TC)、血清甘油三脂 (TG)均有显著差异 (P<0 0 0 1)。毒理学实验表明 ,相当于临床用量的 5 0倍连续给药 90d无毒副反应 ,大鼠的血液生化指标、病理组织学检查与空白组比较无异常 ,提示该药临床应用是安全有效的。
According to the selection procedures of hypoglycemic drugs [1], pharmacodynamics test proved that Xiaokeshu daily doses of 15g/Kg and 7 5g/Kg have a markedly reduced effect on normal blood glucose levels (P < 0 0 5 ) , It has a significant inhibitory effect on adrenaline-induced hyperglycemic mice, and there is a significant difference compared with the blank control group (P < 0 01). It has a significant alleviation effect on alloxan-induced diabetes animals. There was a significant change in blood glucose before and after, continuous feeding to rats for 30 days on the formation of experimental hyperlipidemia compared with hyperlipidemia model group, serum total cholesterol (TC), serum triglyceride (TG) were significantly different (P<0 0 0 1). Toxicological experiments showed that there was 50 times the clinical dose of continuous non-toxic 90 days of continuous administration, and there were no abnormalities in the blood biochemical indicators, histopathological examination, and blank group, suggesting that the clinical application of the drug is safe and effective.