目的观察静脉滴注丙种球蛋白辅助治疗新生儿败血症疗效及外周血清炎性因子影响,指导临床合理治疗,改善临床预后。方法回顾分析2014-2015年在本院出生且符合入组标准的88例新生儿败血症的临床病例资料,其中早产儿25例(28.41%),足月儿63例(71.59%),分析早产儿与足月儿临床特征差异,按治疗方法不同分为观察组和对照组,每组各44例,对照组进行常规方法治疗,观察组在对照组的基础上再静脉注射人血免疫球蛋白,3d后比较两组患儿治疗前后IgG、IL-6、CRP、TNF-α水平变化情况,进行治疗前后自动化血培养检测,记录体温稳定时间与平均住院时间,观察并发症发生率情况,统计病死率,评价两组临床疗效。结果 1)观察组治疗后IgG明显升高,但对照组无明显变化,观察组和对照组治疗后IL-6、CRP、TNF-α明显降低,但观察组治疗后IL-6、CRP、TNF-α明显低于对照组,差异具有显著统计学意义;2)观察组和对照组的体温稳定时间(3.86±2.77)d比(7.46±4.34)d、平均住院时间(15.14±3.41)d比(23.72±9.11)d、血培养转阴率(68.18%比45.15%)、并发症发生率(13.64%比43.18%)、病死率(2.27%比20.45%),差异均具有统计学意义;观察组和对照组总有效率分别为93.18%比79.55%,差异具有统计学意义(χ2=6.416,P<0.05);3)观察组患儿中早产儿14例,显效5例,有效6例,无效3例,13例治愈出院,死亡1例,足月儿30例,显效13例,有效17例,无效0例,均治愈出院,早产儿与足月儿治疗疗效差异具有统计学意义(χ2=6.912,P<0.05),转归差异无统计学意义(χ2=2.193,P>0.05)。结论丙种球蛋白能够通过下调炎症因子水平,抑制炎症反应,提高患儿体液免疫功能,提高抗病能力,缩短血培养转阴时间与治病疗程,降低并发症,改善预后,尤其是足月儿的预后更好。 Objective To observe the effect of intravenous infusion of gamma globulin adjuvant treatment of neonatal sepsis and peripheral serum inflammatory factors, to guide the clinical rational treatment and improve the clinical prognosis. Methods The clinical data of 88 neonates with sepsis born in our hospital from 2014 to 2015 were retrospectively analyzed. Among them, 25 cases (28.41%) were premature infants and 63 (71.59%) full-term infants were analyzed premature infants And full-term children were divided into observation group and control group according to the different treatment methods, 44 cases in each group. The control group was treated by conventional method. The observation group received intravenous injection of human blood immunoglobulin on the basis of the control group, The levels of IgG, IL-6, CRP and TNF-α in the two groups before and after treatment were compared three days later. The blood cultures were detected before and after treatment. The stabilization time and average length of hospital stay were recorded. The complication rates were also observed. Rate, evaluation of two groups of clinical efficacy. Results 1) The IgG in the observation group increased significantly after treatment, but there was no significant change in the control group. The levels of IL-6, CRP and TNF-α in the observation group and the control group were significantly decreased after treatment, but the levels of IL-6, CRP, TNF -α was significantly lower than the control group, the difference was statistically significant; 2) the body temperature stability time (3.86 ± 2.77) d (7.46 ± 4.34) d, the average length of stay (15.14 ± 3.41) d in the observation group and the control group (23.72 ± 9.11) d, blood culture negative rate (68.18% vs 45.15%), complication rate (13.64% vs 43.18%) and case fatality rate (2.27% vs 20.45%). The differences were statistically significant The total effective rate of the group and the control group were 93.18% and 79.55%, respectively, with significant difference (χ2 = 6.416, P <0.05). 3) In the observation group, 14 cases of preterm children, 5 cases markedly effective, 6 cases effective, 3 were ineffective, 13 were cured and discharged, 1 died, 30 were full-term children, 13 were markedly effective, 17 were effective and 0 were ineffective. All were cured and discharged. There was significant difference in curative effect between preterm and full-term children (χ2 = 6.912, P <0.05). There was no significant difference between the two groups (χ2 = 2.193, P> 0.05). Conclusion Gamma globulin can reduce inflammation, reduce inflammatory reaction, improve humoral immune function, improve disease resistance, shorten blood culture time and treatment, reduce complications and improve prognosis, especially in term infants The prognosis is better.