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目的：比较磷酸阿糖腺苷与肝炎灵对乙型肝炎的疗效。方法：慢性乙型肝炎６０例，采用磷酸阿糖腺苷治疗３０例（男性２７例，女性３例，年龄３２±ｓ７ａ），ｄ１－５，１０ｍｇ／ｋｇ，ｉｍ，ｑｄ，ｄ６－２８，５ｍｇ／ｋｇ，ｉｍ，ｑｄ。对照组３０例（男性２６例，女性４例，年龄３０±８ａ），用肝炎灵４ｍＬ，ｉｍ，ｑｄ，共４ｗｋ。结果：ＨＢｅＡｇ和ＨＢＶ－ＤＮＡ阴转率、抗ＨＢｅ阳转率治疗组分别为２３％，１８％，１３％；对照组分别为３％，０，０（Ｐ＜０．０５）。结论：磷酸阿糖腺苷治疗慢性乙型肝炎，具有抑制乙型肝炎病毒（ＨＢＶ）复制的作用，疗效优于肝炎灵。不良反应轻微。
Objective: To compare the therapeutic effect of vidarabine and hepatitis virus on hepatitis B. Methods: 60 cases of chronic hepatitis B were treated with phosphogalactoside (27 males and 3 females, age 32 ± s7a), d1-5, 10 mg / kg, im, qd, d6-28 and 5 mg / Kg, im, qd. Control group of 30 patients (26 males and 4 females, age 30 ± 8a), with hepatitis spirit 4mL, im, qd, a total of 4wk. Results: The negative rate of HBeAg and HBV-DNA, anti-HBe positive rate were 23%, 18% and 13% in the treatment group and 3% and 0,0% respectively in the control group (P <0.05). Conclusion: Phosphoglycoside treatment of chronic hepatitis B, with inhibition of hepatitis B virus (HBV) replication, the effect is superior to hepatitis spirit. Minor adverse reactions.