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目的：阐明对农村孕妇在孕期进行锌干预是否可以改善其不良的妊娠结局。方法：双盲对照法锌干预试验。１５６名孕妇随机分为四组。Ａ、Ｂ和Ｃ组自第一次孕期保健门诊开始至分娩期间每天分别口服补充５ｍｇ、１０ｍｇ和３０ｍｇ剂量的锌，Ｄ组口服安慰剂。结果：膳食调查发现，该人群的膳食结构是以植物性食物为主的非平衡膳食。在妊娠各期，膳食锌平均摄入量为１０ｍｇ／ｄ左右，其中有６５％的锌来源于植物性食物。孕２５周时，Ｃ组和Ｄ组血清锌浓度分别为８．０８±１．８５和６．５３±１．５７μｍｏｌ／Ｌ，两者有统计学差异（Ｐ＜０．０１）；孕３２周时，Ｃ组血清锌浓度（８．６７±１．２７μｍｏｌ／Ｌ）显著高于Ｄ组（６．１７±１．５７μｍｏｌ／Ｌ，Ｐ＜０．０１）。Ｃ组脐血清锌浓度也显著增高。与Ｄ组相比，Ｃ组母亲分娩的婴儿出生体重增加２８３．０７ｇ（Ｐ＝０．０１６），头围增大０．６３ｃｍ（Ｐ＝０．０３５）。Ｃ组Ａｐｇａｒ评分和Ｐｏｎｄｅｒａｌ指数显著高于对照组（Ｐ＜０．０５）。Ｃ组低体重、早产儿及宫内生长发育迟缓婴儿的发生率均显著低于Ｄ组。Ａ组和Ｂ组的妊娠结局及新生儿体格发育指标均与Ｄ组无显著性差异。结论：对摄取以植物性食物为主的非平衡膳食的农村孕妇?
OBJECTIVE: To clarify whether zinc intervention in rural pregnant women during pregnancy can improve their poor pregnancy outcomes. Methods: Double-blind control zinc intervention trial. 156 pregnant women were randomly divided into four groups. Groups A, B and C were orally supplemented with 5 mg, 10 mg and 30 mg doses of zinc orally daily from the first outpatient health clinic until delivery, respectively. Group D received oral placebo. Results: The dietary survey found that the dietary structure of the population was an unbalanced diet based on plant foods. In each phase of pregnancy, the average intake of dietary zinc is about 10mg / d, of which 65% zinc is derived from plant foods. At 25 weeks of pregnancy, serum zinc concentrations in group C and group D were 8.08 ± 1.85 and 6.53 ± 1.57μmol / L, respectively, with statistical significance (P <0.01) , Serum zinc concentration in group C (8.67 ± 1.27μmol / L) was significantly higher than that in group D (6.17 ± 1.57μmol / L, P <0.01). C group cord serum zinc concentration was significantly higher. Compared with group D, the birth weight of infants born to group C mothers increased by 283.07g (P = 0.016) and head circumference increased by 0.63cm (P = 0.035). Apgar score and Ponderal index in group C were significantly higher than those in control group (P <0.05). The incidence of low birth weight, premature infants and intrauterine growth retardation infants in group C were significantly lower than those in group D. Pregnancy outcomes and neonatal physical development in groups A and B were not significantly different from those in group D. CONCLUSIONS: In rural pregnant women who take non-balanced diet based on plant foods?