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目的探讨外源性肺表面活性物质的应用对早产儿外周血T淋巴细胞和NK细胞的影响。方法选择2011年1月-2012年1月应用肺表面活性物质(pulmonary surfactant,PS)治疗的早产儿共30例,测定其应用PS前、应用后3 d血清内SP-A、SP-D,和外周血T淋巴细胞亚群和NK细胞的活性,并以健康足月儿6名为对照组。结果①早产儿应用PS前,血清SP-A、SP-D、CD3+、CD4+、CD16+CD56+比值均低于对照组,差异有统计学意义(P<0.05);而CD4+/CD8+高于对照组;②早产儿应用PS后3天SP-A、SP-D、CD3+、CD4+、CD16+CD56+及CD4+/CD8+比值均有明显升高,差异有统计学意义(P<0.05)。结论应用外源性肺表面活性物质可有效提高早产儿外周血NK细胞数量及CD4+/CD8+比值。
Objective To investigate the effect of exogenous pulmonary surfactant on peripheral blood T lymphocytes and NK cells in preterm infants. Methods A total of 30 preterm infants treated with pulmonary surfactant (PS) from January 2011 to January 2012 were selected and their serum levels of SP-A, SP-D, And peripheral blood T lymphocyte subsets and NK cell activity, and 6 healthy full-term children as the control group. Results ① Before the application of PS, serum SP-A, SP-D, CD3 +, CD4 +, CD16 + CD56 + ratio were lower than the control group, the difference was statistically significant (P <0.05); CD4 + / CD8 + ; ②The SP-A, SP-D, CD3 +, CD4 +, CD16 + CD56 + and CD4 + / CD8 + ratio of preterm infants after PS administration increased significantly on the 3rd day after PS administration, the difference was statistically significant (P <0.05). Conclusion Exogenous pulmonary surfactant can effectively increase the number of NK cells and the ratio of CD4 + / CD8 + in peripheral blood of premature infants.