多发性硬化(multiple sclerosis,MS)是最常见的中枢神经系统自身免疫性炎性脱髓鞘疾病。根据病程可分为复发缓解型(relapsing-remitting multiple sclerosis,RRMS)、继发进展型(secondary progressive multiple sclerosis,SPMS)、原发进展型(primary progressive multiple sclerosis,PPMS)和进展复发型(progressiverelapsing multiple sclerosis,PRMS)。儿童MS以RRMS为主,PPMS罕见。虽然该病多见于成人,但随着对MS Multiple sclerosis (MS) is the most common central nervous system autoimmune inflammatory demyelinating disease. According to the course of the disease, it can be divided into relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), primary progressive multiple sclerosis (PPMS) and progressive relapsing multiple sclerosis, PRMS). Children MS mainly RRMS, PPMS rare. Although the disease more common in adults, but with the MS