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心肌梗塞后非缺血部分的心肌通常认为是“正常心肌”。然而,现有相当多的证据提示,存活心肌的心肌收缩力和代谢有明显改变。本文旨在了解心肌梗塞后早期当儿茶酚胺明显增高时,心肌收缩性和肌膜代谢改变的特征。方法:取体重300～350克的雌性豚鼠,开胸结扎冠状动脉左回旋支的第1和第2边缘支,造成左室游离壁梗塞。为了估计儿茶酚胺对心肌的影响,部分豚鼠在结扎冠状动脉前24和3小时皮下注射利血平5毫克/公斤,或从术后3小时起每天2次皮下
Myocardial infarction non-ischemic part of the myocardium is usually considered to be “normal myocardium.” However, there is considerable evidence to suggest that there is a significant change in myocardial contractility and metabolism of viable myocardium. This article aims to understand the early myocardial infarction when catecholamines significantly increased myocardial contractility and changes in the characteristics of the myometrium. METHODS: Female guinea pigs weighing 300-350 g were anesthetized by thoracotomy and ligation of the first and second marginal branches of the left circumflex coronary artery, resulting in left ventricular free wall infarction. In order to assess the effect of catecholamines on cardiac muscle, some guinea pigs were injected subcutaneously with reserpine 5 mg / kg 24 and 3 hours prior to ligation of the coronary arteries or 2 times daily 3 hours after surgery