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目的观察外基质金属蛋白酶诱导因子(EMMPRIN)联合血清绒毛膜促性腺激素(β-h CG)、雌二醇(E_2)、孕酮(P)检测诊断孕妇胎膜早破的价值。方法选取2014年5月-2016年6月该院诊治的孕妇胎膜早破患者30例,设为观察组,选取同期入院的健康孕妇30例,设为对照组。采用酶联免疫吸附法对EMMPRIN进行定位及半定量检测;采用放射免疫法检测血清中β-h CG、E_2、P水平。结果观察组孕妇绒毛中“-”性率、“+”性率显著低于对照组孕妇,差异有统计学意义(P<0.05);观察组“++”、“+++”阳性率显著高于对照组差异有统计学意义(P<0.05);观察组孕妇血清β-h CG、E_2、P水平显著低于对照组(P<0.05);相关性研究结果显示:孕妇胎膜早破发生率与EMMPRIN、血清β-h CG、E_2及P水平呈正相关性(P<0.05)。结论孕妇胎膜早破患者动态监测EMMPRIN联合血清β-h CG、E_2、P水平效果理想,能了解患者病情变化情况,值得推广应用。
Objective To observe the value of extraneous matrix metalloproteinase inducer (EMMPRIN) in combination with serum chorionic gonadotropin (β-h CG), estradiol (E2) and progesterone (P) in the diagnosis of premature rupture of membranes in pregnant women. Methods From May 2014 to June 2016, 30 pregnant women with premature rupture of membranes who were diagnosed and treated in this hospital were selected as the observation group. Thirty healthy pregnant women were selected as the control group. Enzyme-linked immunosorbent assay was used to locate and semi-quantitatively detect EMMPRIN. Serum β-h CG, E_2, P levels were measured by radioimmunoassay. Results In the observation group, the rate of “-” and “+” in the villus of pregnant women was significantly lower than that of the pregnant women in the control group (P <0.05) (P <0.05). The levels of serum β-h CG, E 2 and P in the observation group were significantly lower than those in the control group (P0.05) The results showed that: The incidence of premature rupture of membranes in pregnant women and EMMPRIN, serum β-h CG, E 2 and P levels were positively correlated (P <0.05). Conclusions EMMPRIN and serum levels of β-h CG, E_2 and P in pregnant women with premature rupture of membranes are effective in monitoring the changes of patients’ condition, which is worth popularizing and applying.