论文部分内容阅读
磁性纳米粒子肿瘤热疗技术是目前国际上肿瘤研究的热点.本文提出了一种基于超声驱动磁性纳米粒子(UDMNP)运动进行肿瘤细胞灭杀的新技术,实现磁性纳米粒子的肿瘤治疗.系统研究了肝癌肿瘤细胞HepG2的治疗效果,在一定超声频率下,改变超声功率和超声作用时间,UDMNP具有明显灭杀效果.实验结果显示,较小超声功率下,肿瘤细胞损伤较小,随着超声功率增加,UDMNP对肿瘤细胞表现出明显的灭杀作用.同时,随着作用时间增加,同一超声功率驱动下UDMNP对细胞的灭杀效果也明显提高,光学显微镜观察到细胞形态发生明显变化.本文提出的UDMNP肿瘤细胞灭杀方法的显著优势是减少了化学毒性和有害辐射,是一种物理性机械损伤技术,对促进磁性纳米粒子的临床医学应用有重要意义.
Magnetic nanoparticle tumor hyperthermia is currently a hot research topic in the world of oncology.This paper presents a new technique based on ultrasound-driven movement of magnetic nanoparticles (UDMNP) to kill tumor cells, and to achieve the tumor therapy of magnetic nanoparticle. The therapeutic effect of HepG2 hepatoma tumor cells under certain ultrasonic frequency, change the ultrasonic power and ultrasonic action time, UDMNP has a significant killing effect.Experimental results show that smaller ultrasound power, less damage to tumor cells, with the ultrasonic power UDMNP showed a significant killing effect on tumor cells.At the same time, with the increase of the action time, the killing effect of UDMNP on cells under the same ultrasound power was also significantly increased, and the morphological changes of cells were observed under optical microscope.This paper proposed The significant advantage of the UDMNP tumor cell killing method is to reduce the chemical toxicity and harmful radiation. It is a kind of physical mechanical damage technology, which is of great significance to promote the clinical application of magnetic nanoparticles.