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目的:探讨干扰素与拉米夫定治疗慢性乙型肝炎的成本-效果.方法:选取我院72例慢性乙型肝炎患者,分成干扰素组(干扰素治疗)与拉米夫定组(拉米夫定治疗),对比两组治疗慢性乙型肝炎的成本-效果.结果:两组患者HBeAg 转阴率存在显著差异(P<0.05);拉米夫定组成本-效果明显优于干扰素组(P<0.05).结论:拉米夫定治疗慢性乙型肝炎的成本-效果优于干扰素,但拉米夫定因不确定疗程等问题,临床中需结合理选择药物.“,”Objective To investigate the cost-effectiveness of interferon and lamivudine in the treatment of chronic hepatitis B.Methods 72 cases of chronic hepatitis B patients, divided into interferon (IFN treatment) group and lamivudine group (lamivudine), compared two groups of treatment of chronic hepatitis B with cost effectiveness.Results Two groups of patients with HBeAg negative rate, there was a significant difference (P< 0.05); Lamivudine group cost - effect is obviously superior to the interferon group (P < 0.05).Conclusion lamivudine treatment of chronic hepatitis B is the cost - effect is better than interferon, but lamivudine because of the uncertainty of the treatment and adverse reactions and other issues, the need to choose a reasonable clinical drug.