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目的探讨糖尿病慢性肾脏疾病(CKD)患者血清色素上皮衍生因子(PEDF)水平变化及其临床意义。方法 选取CKD患者152例,根据24 hUAER分为正常白蛋白尿组(NA组)、微量白蛋白组(MA组)和临床白蛋白尿组(PR组)。另选取健康人群(NC组)38名。检测各组PEDF、血管内皮因子(VEGF)、HbA_1c、C-RP、FPG等水平。结果 PR组PEDF水平高于其他组。各组SBP、PEDF、C-RP、24 hUAER、VEGF比较,差异均有统计学意义(P<0.05)。相关分析显示,血清PEDF与C-RP、HbA_1c、FPG、UAER和VEGF呈正相关(r=0.302、0.207、0.382、0.189、0.523,P<0.05);多元线性逐步回归分析显示,24 hUAER和C-RP是血清PEDF独立相关因素(β=0.61、0.18,P<0.05)。结论 CKD患者血清PEDF水平升高,其升高可能与CKD的发生发展有关。
Objective To investigate the changes of serum pigment epithelium-derived factor (PEDF) in patients with chronic kidney disease (CKD) and its clinical significance. Methods Fifty-two CKD patients were divided into normal albuminuria group (NA group), microalbumin group (MA group) and clinical albuminuria group (PR group) according to 24 hUAER. Another 38 healthy people (NC group). The levels of PEDF, vascular endothelial growth factor (VEGF), HbA 1c, C-RP and FPG in each group were detected. Results The PEDF level in PR group was higher than that in other groups. The differences of SBP, PEDF, C-RP, 24 hUAER and VEGF in each group were statistically significant (P <0.05). Correlation analysis showed that serum PEDF was positively correlated with C-RP, HbA 1c, FPG, UAER and VEGF (r = 0.302,0.207,0.382,0.189,0.523, P <0.05). Multiple linear stepwise regression analysis showed that 24 hUAER and C- RP was independently associated with serum PEDF (β = 0.61, 0.18, P <0.05). Conclusions Serum levels of PEDF are elevated in patients with CKD, which may be related to the occurrence and development of CKD.