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微小RNA(miRNA)作为一种新的遗传物质,是近年分子生物学研究的热点之一,其与肿瘤发病机制的研究越来越深入。miRNA是一类长度约21~25个核苷酸的内源性非编码RNA,主要与靶基因的3’非翻译区结合,并参与基因的转录后表达。而垂体腺瘤是一种常见颅内肿瘤,发病率仅次于胶质瘤、脑膜瘤,约占颅内肿瘤的15%。近年研究发现:miRNA参与垂体腺瘤的细胞增殖、分化、凋亡,与肿瘤发生、发展密切相关。本文主要介绍miRNA在垂体腺瘤发病机制中的研究进展。
MicroRNAs (miRNAs), as a new genetic material, are one of the hot topics in molecular biology in recent years. Their research on the pathogenesis of tumors has become more and more in-depth. MiRNAs are a class of endogenous noncoding RNAs of about 21-25 nucleotides in length that bind primarily to the 3 ’untranslated region of the target gene and are involved in post-transcriptional gene expression. Pituitary adenoma is a common intracranial tumor, the incidence of glioma, meningioma, accounting for about 15% of intracranial tumors. Recent studies have found that: miRNAs are involved in the proliferation, differentiation and apoptosis of pituitary adenomas and are closely related to tumorigenesis and development. This article describes the progress of miRNA in the pathogenesis of pituitary adenoma.