关于生物钟调节机体各项生理机能的研究引起了人们极大的兴趣,随着研究的不断深入,近年来从分子生物学的水平已经发现多种神经介质,如去甲肾上腺素(NE)、多巴胺(DA)、乙酰胆硷(ACh)和鸦片肽等的代谢,在每日24小时中也发生规律性周期变化。中枢神经介质作为神经调节中重要信息物质,自突触前释放后首先与其相应受体发生特异性的相互作用,进而激发细胞内一系列环节而最后发挥其生理功能。因此,伴随神经介质代谢的生物节律变化,是否同时发生受体的节律性变化,成为一个吸引人的问题。美国国立精神卫生研究院的Naber等人对此曾进行了大量的研究工作。他们曾报告过NE α和β受体 Research on various physiological functions of the circadian clock to regulate the body has aroused great interest. With the deepening of the research, in recent years, it has been discovered from the level of molecular biology that various neurotransmitters such as norepinephrine (NE), dopamine (DA), acetylcholine (ACh) and opioid peptides, etc., regular cyclical changes also occur 24 hours a day. As an important information substance in neuromodulation, CNS mediates the specific interaction with its corresponding receptor after its release from the presynaptic state, which in turn stimulates a series of intracellular processes and finally exerts its physiological function. Therefore, with the change of circadian rhythm of neurotransmitter metabolism, whether rhythmic changes of receptors occur simultaneously becomes an attractive problem. Naber and others at the National Institute of Mental Health have done a great deal of research. They have reported NE α and β receptors