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目的:分析颅内压监测下亚低温治疗重型颅脑损伤(s TBI)患者的临床效果。方法:将2013年7月至2016年7月南阳市唐河县人民医院重症监护病房(ICU)收治的100例s TBI患者作为研究对象,按随机数字表法分为对照组与观察组各50例,入院后均进行对症处理,观察组加用亚低温治疗,控制直肠温度(RT)为32~34℃,对照组控制RT为36~37℃,均监测患者脑组织氧分压(PbtO_2)与颅内压(ICP),结果:入院时,两组ICP、PbtO_2比较差异无统计学意义(P>0.05),入院24 h、48 h、72 h、96 h,两组ICP、PbtO_2均降低,观察组入院不同时间点ICP、PbtO_2均低于对照组(P<0.05)。结论:ICP监测下亚低温治疗s TBI可快速降低患者ICP,改善其神经功能及预后。
Objective: To analyze the clinical effect of intracranial pressure monitoring for mild hypothermia in patients with severe head injury (s TBI). Methods: From January 2013 to July 2016, 100 cases of s TBI patients treated in Intensive Care Unit (ICU) of Tanghe People’s Hospital of Nanyang City were enrolled and divided into control group and observation group according to random number table Patients were admitted to the hospital after symptomatic treatment, the observation group with mild hypothermia treatment, rectal temperature control (RT) was 32 ~ 34 ℃, the control group was controlled at 36 ~ 37 ℃, were monitored in patients with brain tissue partial pressure of oxygen (PbtO_2) ICP and ICP. Results: There were no significant differences in ICP and PbtO_2 between the two groups at admission (P> 0.05). After admission for 24 h, 48 h, 72 h and 96 h, both ICP and PbtO 2 decreased , While the ICP and PbtO_2 in the observation group were lower than those in the control group at different time points (P <0.05). CONCLUSIONS: Sub-hypothermia treatment with sIgI under ICP can rapidly reduce ICP and improve neurological function and prognosis.