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用细胞内微电极技术记录正常和部分除极豚鼠乳头肌动作电位，研究双苯氟嗪（３－３０μｍｏｌ·Ｌ－１）对豚鼠乳头肌细胞电生理的影响．结果表明，双苯氟嗪轻度缩短正常乳头肌动作电位的平台期（ＰＰＤ），５０％和９０％复极化时程（ＡＰＤ５０和ＡＰＤ９０），但对静息电位（ＲＰ），动作电位幅度（ＡＰＡ），超射（ＯＳ）和０相最大上升速率（Ｖｍａｘ）均无显著影响．在高Ｋ＋部分去极化的豚鼠乳头肌标本，双苯氟嗪可轻度降低慢反应动作电位的ＯＳ，ＡＰＡ和Ｖｍａｘ，并缩短ＰＰＤ，ＡＰＤ５０和ＡＰＤ９０，对ＲＰ同样无显著影响．在相同浓度下，双苯氟嗪对离体豚鼠乳头肌动作电位的影响与氟桂利嗪无显著差别．提示双苯氟嗪在较高浓度时，可轻度缩短豚鼠乳头肌的复极过程及降低部分除极乳头肌的ＯＳ，ＡＰＡ和Ｖｍａｘ．
The effect of dipfluzine (3-30 μmol·L -1) on the electrophysiology of guinea pig papillary muscle cells was investigated by using intracellular microelectrode technique to record the action potentials of normal and partial depolarized guinea pig papillary muscles. The results showed that dipfluzine mildly shortened the PPD, 50% and 90% APD50 and APD90 of normal papillary muscles, but had no significant effect on resting potential (RP), action potential amplitude APA, OS and Vmax. In high-K + partially depolarized guinea pig papillary muscle samples, dipfluzine mildly reduced the OS, APA and Vmax and slowed PPD, APD50 and APD90 of the slow response action potentials, with no significant effect on RP. At the same concentration, the effect of dipfluzine on the action potential of guinea pig papillary muscles was not significantly different from that of flunarizine. Tip dipfluzine at higher concentrations, can be mildly shortened guinea pig papillary muscle repolarization process and reduce part of the depolarized papillary muscles of the OS, APA and Vmax.