目的　探讨多发性骨髓瘤的临床特征。方法　复习６５ 例多发性骨髓瘤患者初诊时的临床资料。结果与结论　患者绝大多数为中老年人，但较国外患者年轻；蛋白尿、贫血、骨痛为主要临床表现；骨质病变程度与骨髓中的瘤细胞数无显著相关；对于骨髓中瘤细胞数较高者， Ｖ Ａ Ｄ 方案疗效较好；阿可达可能对骨质破坏有阻抑作用。 Objective To investigate the clinical features of multiple myeloma. Methods Review the clinical data of 65 patients with multiple myeloma at the time of initial diagnosis. Results and Conclusions The vast majority of patients were middle-aged and elderly, but younger than foreign patients; proteinuria, anemia, and bone pain were the main clinical manifestations; the degree of bone lesions was not significantly associated with the number of tumor cells in bone marrow; for bone marrow cells The higher the number, the better efficacy of the V A D regimen; Argao may have a deterrent effect on bone destruction.