肿瘤侵袭转移是恶性肿瘤危及患者生命最主要的恶性行为特征,也是导致肿瘤患者死亡的主要原因之一。肿瘤诱导血管生成对肿瘤转移的影响已为研究者重视,而肿瘤转移主要方式之一的淋巴转移分子机制却长期未被重视。由于淋巴管较脆,在解剖中不易得到,以及病理上对淋巴管内皮细胞的 Tumor invasion and metastasis is one of the major causes of malignant tumor which endanger the life of patients and the leading cause of death of cancer patients. The effect of tumor-induced angiogenesis on tumor metastasis has been paid more attention to by researchers, and the molecular mechanism of lymphatic metastasis, one of the main ways of tumor metastasis, has long been neglected. As lymphatic vessels more brittle, difficult to obtain in the anatomy, and pathological lymphatic endothelial cells