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目的：探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease﹐COPD)患者急性加重期(acute exacrbations of chronic obstructive pulmonary diseases, AECOPD)和稳定期呼出气一氧化氮(FENO)水平变化的临床意义﹐及其与FEV1﹐FEV1﹪的相关性。方法纳入81例COPD急性加重期到稳定期为研究组﹐78例健康者为对照组﹐行FENO﹑肺功能检查﹐记录FENO﹑FEV1﹑FEV1﹪值。结果①COPD患者急性加重期组FENO水平高于稳定期组﹔②COPD稳定期组FENO水平高于对照组﹔③COPD急性加重期组FENO水平高于稳定期组和对照组(0.05)﹔COPD稳定期组患者FENO水平与FEV1﹑FEV1﹪均无相关性(>0.05)﹔急性加重期到稳定期FENO改善值与急性加重期到稳定期FEV1改善值之间存在正相关关系(0.05);Acute exacerbation period to stabilization FENO improve value with acute aggravating period to stability improved FEV1 value between positive correlation ( < 0.05), with acute aggravating period to improve stability FEV1%value also exists between the positive correlation ( <0.05). Conclusion FENO may occur in the COPD and play an important role in the process of development, is probably reflect the index of acute exacerbation of COPD patients.