人类抵抗素主要在单核细胞和巨噬细胞中表达,具有抵抗胰岛素的作用。然而,目前许多研究表明抵抗素与冠心病具有密切关系,一方面,急性心肌损伤通过斑块的破裂、炎性反应和应激等机制可刺激血浆抵抗素水平升高;另一方面,血浆抵抗素水平升高通过引起血管内皮细胞功能紊乱,诱导炎症反应和氧化应激,促进泡沫细胞的形成,促进血管平滑肌细胞增殖、迁移,促进血管内皮细胞增殖、迁移及毛细血管生成和促进冠状动脉钙化等机制导致冠心病。 Human resistin is mainly expressed in monocytes and macrophages and has the effect of resisting insulin. However, many studies have shown that resistin is closely related to coronary heart disease. On the one hand, acute myocardial injury can stimulate plasma resistin through mechanisms such as plaque rupture, inflammatory reaction and stress; on the other hand, plasma resistance Elevated levels of blood lead to vascular endothelial dysfunction, induce inflammatory reactions and oxidative stress, promote the formation of foam cells, promote the proliferation and migration of vascular smooth muscle cells, promote the proliferation and migration of vascular endothelial cells and angiogenesis and promote coronary artery calcification Other mechanisms lead to coronary heart disease.